The latest release of the MHRA’s Drug Safety update has been released and highlights the following:

• Modafinil (Provigil): increased risk of congenital malformations if used during pregnancy
• Pirfenidone (Esbriet): risk of serious liver injury; updated advice on liver function testing
• Ferric carboxymaltose (Ferinject▼): risk of symptomatic hypophosphataemia leading to osteomalacia and fractures
• Bupropion (Zyban): risk of serotonin syndrome with use with other serotonergic drugs
• Isotretinoin (Roaccutane▼): contribute to expert review

The full release document can be viewed here